BCAA GOLD are a new and exclusive supplement containing KyowaQuality® branched- chain essential amino acids (L-leucine, L-isoleucine and L-valine) mixed in ratios of 2:1:1, in 1 g tablets with acetyl carnitine EsterDrive. BCAA Tablets are taken a few minutes before training in the gym because they strongly reduce muscle catabolism, rapidly providing energy and increasing the athlete’s resistance to fatigue; taken after the workout, they stimulate protein synthesis and speed up muscle recovery. BCAA Tablets are made from a granular mixture of active ingredients that can be submitted to a low-pressure tablet compressing process in association with EsterDrive, ensuring the best possible dissolvability in liquids and the shortest assimilation time, all to the advantage of the athlete using the product. Acetyl-carnitine is a nitrogenated physiological substance responsible for transporting fatty acids inside the inner mitochondrial membrane to induce beta-oxidation and convert them into a source of energy for the cell.
Recent scientific studies have demonstrated that various forms of carnitine, and particularly N-acetyl carnitine and the acylcarnitines, significantly
facilitate the intestinal absorption of various classes of molecules used in pharmaceuticals and nutrition, including amino acids and nitrogenated
It has been reported that L-acetyl carnitine is capable of increasing the enteral absorption of these substances for two hours after its ingestion, and
the mechanism of action is presumably related to an increased permeability of the intestinal mucosa and of the single enterocytes.
Indications: BCAA are metabolized in the mitochondria; valine is converted into a molecule of succinyl-CoA, a Krebs cycle intermediate; isoleucine
generates one molecule of succinyl-CoA and one of acetyl-CoA; and the complete catabolism of leucine produces three molecules of acetyl-CoA, and
this process continues in the Krebs cycle until oxidation is complete.
The principal point where BCAA catabolism is regulated is on a level with the branched-chain ketoacid dehydrogenase (BCKDH) poly-enzyme complex.
This mechanism enables BCAA catabolism to be activated, providing the diet is rich in these amino acids. BCKDH is also activated by low levels of
ATP and pH, by glycogen depletion, and by physical exercise. It is worth noting that, in addition to promoting protein catabolism, sports training also
causes an increase in the density and dimension of the mitochondria in the muscle fiber cells - an adaptation mechanism that already gives rise to a
greater capacity to oxidize the branched-chain amino acids.
A plentiful supply of amino acids generally seems to activate protein synthesis, while a shortage of essential amino acids has a limiting effect. An
abundance of BCAA (and leucine in particular) in the muscle fibers has a further, powerful anabolic effect. To see how BCAA take effect in regulating
the processes of protein synthesis and degradation, we need to be aware that insulin, IGF-1 and GH influence these same processes too.
The effect may be due to the vasodilation induced by the production of nitric oxide, stimulated by the guanylyl cyclase on the capillary endothelium - an
important component in the mechanisms by means of which GH, IGF-1, insulin and amino acids promote an increase in muscle proteins (anabolism).
Concerning insulin, it seems that its contribution at the time of the ingestion of branched-chain amino acids induces a further positive effect on protein
anabolism, because it appears to change the muscle’s metabolic status from catabolic to anabolic. It has been suggested that this effect is mediated
by the amino acids’ entry inside the cells being facilitated.
Leucine is much more powerful than isoleucine, which in turn is more effective than valine, in directly stimulating protein synthesis and inhibiting cell
The physiological mechanism by means of which leucine regulates protein synthesis in the body is an important issue. The changes in muscle tissue
induced by physical exercise are supported by the expression of various genes. These genes’ expression is regulated on various levels, ranging from
DNA transcription to transduction. The signal triggered by leucine seems to increase the availability of a factor indispensable to the initiation of
More light has recently been shed on how the degradation of muscle proteins is controlled. It seems that glucocorticoids, and a shortage of amino
acids (including the BCAA, and leucine in particular) stimulate muscle proteolysis, whereas IGF-1 and insulin inhibit it.
The use of Pro Muscle BCAA GOLD, and of BCAA generally, is common practice among sports practitioners.
It has been reported that taking BCAA before exercising increases their blood and tissue levels, and this increase coincides with an inhibitory effect
on muscle protein degradation, consequently facilitating anabolism.
Another effect of Pro Muscle BCAA seems to relate to the mechanism of central fatigue, a condition defined as the inability to
complete a physical effort due to events relating to the central nervous system.
One of the explanations for central fatigue lies in an increase in the amount of tryptophan uptake by the brain, which leads to an excessive production of
serotonin. The transportation of tryptophan inside the brain depends on the concentration of the other neutral long-chain amino acids in the blood, and the
BCAA in particular, which compete with tryptophan for transit through the blood-brain barrier. The greater the decline in the concentration of BCAA, the
greater the quantity of tryptophan that succeeds in reaching the brain, and the stronger the resulting sense of fatigue. An adequate BCAA supplementation
could consequently prevent the onset of symptoms of fatigue during strenuous exercise. The mechanism by means of which the BCAA provided by Pro
Muscle BCAA Tablets have their positive effect on muscle protein anabolism is probably related to the above-described mechanisms.
In addition, because there is an increased oxidation of branched-chain amino acids, glucides, lipids and muscle proteins during physical exercise to
generate energy, supplementation with BCAA provides an additional source of energy that can have a positive effect on the success of training by inhibiting
glucose oxidation in the muscles, which means a saving and a slower hepatic gluconeogenesis, and a consequently better performance. Some studies
have emphasized a likely difference between males and females in terms of the energy substrates preferentially used during physical activity. Generally
speaking, it seems that women oxidize lipids rather more, and carbohydrates and amino acids rather less than men during aerobic exercises.
Use: 5 tablets a day before or after exercising.
Ingredients: L-leucine, L-isoleucine, L-valine, Stabilizers: microcrystalline cellulose, sodium carboxymethylcellulose, Anticaking agents: magnesium
stearate, silicon dioxide; [Easter-Drive (L-acetyl carnitine), pyridoxine hydrochloride (vitamin B6), thiamine hydrochloride (vitamin B1), cyanocobalamin
Precautions: Seek a doctor’s advice in the event of prolonged use (more than 6 to 8 weeks). The product is contraindicated in cases of renal disease,
pregnancy and children under 14 years of age. Keep out of reach of children under three years old. It is important to adopt a varied and balanced diet, and
a healthy lifestyle. Keep in a cool dry place.